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关于举行新加坡南洋理工大学Sing Yian Chew教授和法国南特大学Catherine Le Visage教授学术报告会的通知
- 来源：
- 学校官网
- 收录时间：
- 2025-10-18 15:47:06
- 时间：
- 2025-10-21 09:30:00
- 地点：
- 广州国际校区C1-b115
- 报告人：
- Sing Yian Chew, Catherine Le Visage
- 学校：
- -/-
- 关键词：
- extracellular matrix, nerve repair, tissue engineering, biomimetic scaffolds, RNA interference, remyelination, spinal cord injury, intervertebral disc regeneration, bioinspired materials, hydrogels, 3D bioprinting, stem cells, growth factors
- 简介：
- The extracellular matrix (ECM) microenvironment is a key regulator of cell fate and tissue regeneration. By designing tissue-engineered scaffolds that emulate the essential biophysical and biochemical features of the natural ECM, we can better direct cellular behavior and promote functional tissue outcomes. In this presentation, I shall discuss our recent work on engineering biofunctional scaffolds integrated with biomolecular cues, highlighting the use of RNA interference to enhance nerve regeneration and remyelination. I shall also present findings from our studies on human spinal cord progenitor cell transplantation for spinal cord injury repair. Particular emphasis will be placed on fiber-based constructs that recapitulate the architecture and size-scale of the native ECM, as well as 3D-printed scaffolds that enable customizable and application-specific designs. Intervertebral disc degeneration is a leading cause of chronic low back pain, imposing significant socioeconomic and healthcare burdens worldwide. Conventional clinical interventions, such as spinal fusion and artificial disc replacement, are often associated with long-term complications and fail to replicate the complex structural, mechanical, and biological functions of the native disc. Recent advances in biomaterials science offer a promising avenue for regenerative therapies that aim to restore disc function through bioinspired design principles. This talk will explore the development of next-generation biomaterials engineered to mimic the hierarchical architecture and multifunctionality of the native IVD. Emphasis will be placed on the integration of tissue-specific mechanical properties, anisotropic load-bearing capabilities, and cellular microenvironments conducive to disc regeneration.
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报告介绍：
报告题目1：Engineering Extracellular Microenvironments to Direct Nerve Repair 主 讲 人： Sing Yian Chew（新加坡南洋理工大学教授） 报告题目2：Bioinspired materials for intervertebral disc regeneration 主 讲 人： Catherine Le Visage（法国南特大学教授） 报告时间： 2025年10月21日（星期二）9:30-12:00 报告地点： 广州国际校区C1-b115 主办单位： 生物医学科学与工程学院、生物医学材料教育部重点实验室（华南理工大学）、国家人体组织功能重建工程技术研究中心
报告人介绍：
Dr. Sing Yian Chew is a Professor at the School of Chemistry, Chemical Engineering and Biotechnology, the Lee Kong Chian School of Medicine and the School of Materials Science and Engineering at Nanyang Technological University, Singapore. She is also an International Fellow of Tissue Engineering and Regenerative Medicine (FTERM). Dr. Chew is known for her contributions in designing biomimetic scaffolds to understand and control cell fate. Her most significant contribution is in the field of scaffold-mediated delivery of gene-silencing and biomimicking physical signals for neural tissue regeneration and remyelination. Dr. Chew is an Associate Editor at ACS Applied Materials & Interfaces. She also serves as the editorial board member of Biomaterials, Experimental Neurology, Tissue Engineering, Journal of Biomedical Materials Research, Part A, Drug Delivery and Translational Research.
Dr. Catherine Le Visage trained as a Pharmacist, received her Ph.D. in Pharmaceutical Sciences, and then performed a post-doc at the Johns Hopkins University (USA). She then joined the French National Institute of Health and Medical Research in a tenured position. Her most recent works as a group leader have focused on innovative hydrogels as i) carriers of cells or bioactive molecules in the context of intervertebral disc disease and osteoarthritis and ii) biofabrication tools for developing advanced in vitro models. Dr. Catherine Le Visage is Chair-Elect of TERMIS-EU, an International Fellow of Tissue Engineering and Regenerative Medicine (FTERM) and a member of the French Academy of Pharmacy. She is an Associate Editor for Biomaterials (Elsevier).
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