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药学院·云轩创新药物论坛：Multi-Disciplinary Approaches for Precision Delivery of Bio-Therapeutics
- 来源：
- 学校官网
- 收录时间：
- 2026-06-25 20:16:39
- 时间：
- 2026-06-02 09:00:00
- 地点：
- Conference Room 2108, Yunxuan Building
- 报告人：
- S. De Smedt
- 学校：
- 苏州大学
- 关键词：
- bio-therapeutics, nucleic acids, lipid nanoparticles, mRNA vaccines, drug delivery, precision medicine, nanomedicine, gene editing, RNA biology
- 简介：
- Over the past 30 years protein bio-therapeutics experienced major clinical successes and nowadays represent the fastest growing category of drugs. Meanwhile, progress in the understanding of RNA biology has led to the identification of new RNA classes with unanticipated functions. Following these advances new therapeutic strategies based on nucleic acids have been introduced. Examples are single stranded antisense oligonucleotides, double stranded small interfering RNAs and microRNAs, all for inhibiting gene expression and, most recently, single guide RNAs for the editing of mutated genes. In addition to nucleic acids which silence or edit genes, there is a major interest as well in the therapeutic potential of messenger RNAs to express proteins in cells for e.g. vaccination to protect the population against infections or to treat cancer patients. As 30-40 years ago, when recombinant proteins and monoclonal antibodies began to be developed as therapeutics, it seems that with nucleic acid bio-therapeutics we are again on the brink of a revolution in drug development. Today the majority of clinically advanced nucleic acids are systemically injected and tested for liver associated diseases. However, numerous potential targets for nucleic acids are present in tissues beyond the liver, like in the lungs and the eyes, which can best be reached through local administration of the nucleic acids, like through inhalation in the lungs or local injections in the eye.
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报告介绍：
At Ghent University we undertake efforts for a better understanding of the physicochemical and biopharmaceutical understanding of nanomedicines, including lipid nanoparticles (LNPs) loaded with nucleic acids, this to improve their delivery performance and safety. Though, while the clinical introduction of mRNA vaccines has boosted the interest and investments by the pharmaceutical industry into the further development of LNPs, at university we consider it our role to keep on trying to identify new concepts and strategies which might open new avenues for the delivery of bio-therapeutics to targets which cannot be reached through nanoencapsulation. This lecture will explain our recent efforts in finding strategies to deliver nucleic acids from the extracellular space, over cell- and organelle-membranes, into the cytosol. Both pharmaceutical, biological, physical and engineering aspects of our work will be highlighted. A special emphasis will be on the delivery of nucleic acids to targets in the eye.
报告人介绍：
S. De Smedt (Ghent University – Belgium, www.drugdelivery.be)
报告图片：
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